Edward who seem to have everything in life has nothing except for his wealth. He had been through a lot of divorces and has a missing daughter. While Carter is a quiet man who works hard for his family. He's been married for 40 years to his wife and has two sons- a lawyer and an engineer and a daughter who is a violinist.
While sharing a hospital room together, they decide to leave and do all the things that they have ever wanted to do before they die according to their bucket list.
They began an around-the-world vacation, tried race car driving, skydiving, climbing the Pyramids, and going on lion safari in Africa. Along the way, they discuss faith and family, and learn from each other that Carter has long been feeling less in love with his wife and that Edward is deeply hurt by his estrangement with his only daughter, who disowned him after he sent some people to "take care of" her abusive husband.
In Hong Kong, Edward hires a prostitute for Carter, who had remained faithful to his wife for the 40 years of their marriage. Carter declined the prostitute finding that the love he had for his wife is still strong. He asks to return home, and in gratitude for helping him, he tries to reunite Edward with his daughter. Edward lacks the courage to face her, however, then he angrily storms off. Carter returns home to his wife, children, and grandchildren.
The family reunion was short lived for Carter's cancer had spread to his brain. He had a surgery but the procedure was unsuccessful. At Carter's funeral, Edward said that his friend had saved him. His life with Carter was one of his bests.
Edward then had the courage to face his daughter. He was not only accepted but also he was introduced to his granddaughter, fulfilling his goal to "kiss the most beautiful girl in the world".
Later on Edward also died and had his ashes placed inside a can,just like Carter's. The cans were placed side by side buried in Mt. Everest.
Carter truly had saved Edward for "When he closed his eyes, his heart was opened."